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KMID : 0043320080310030364
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Archives of Pharmacal Research
2008 Volume.31 No. 3 p.364 ~ p.369
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Intracerebroventricular Gisenosides are Antinociceptive in Proinflammatory Cytokine-Induced Pain Behaviors of Mice
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Seo Young-Jun
Kwon Min-Soo
Choi Hee-Woo
Jang Jeong-Eun
Lee Jin-Koo
Sun Yuan-Jie
Jung Jun-Sub
Park Soo-Hyun
Suh Hong-Won
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Abstract
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Several ginsenoside () are neuroprotective and antinociceptive agents. In this study, we assessed the effects of these ginsenosides following intracerebroventricular (i.c.v) administration on the nociceptive behaviors induced by intrathecal injection of pro-inflammatory cytokines (tumor necrosis factor-a , interleukin-, and interferon-). The ginsenosides, significantly attenuated the nociceptive behavior induced by , , and injection, but ginsenoside- did not. These results suggest that several ginsenosides may regulate the nociceptive processing induced by pro-inflammatory cytokines.
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KEYWORD
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Ginsenoside, Anti-nociception, Pain behaviors, Pro-inflammatory cytokines
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